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Bioanalyst (LC-MS expert)

Location: CAMBRIDGESHIRE, EAST ANGLIA Salary: Salary Negotiable
Sector: Scientific Job Type: Permanent
Shift Type: DAYS ONLY Applications: N/A
Posted: 12 months ago Reference: 3116976
Due to an expansion of client base, an exciting opportunity has arisen within a Cambridgeshire based CRO for an individual to set up and establish an LC-MS/MS service to support both GxP (GLP and GCP(labs)) and non-GxP studies. The position will involve the establishment of an LC-MS/MS instrument within an established laboratory to work alongside colleagues in designing and delivering bioanalytical projects for a variety of clients. The CRO already provides a wide range of services to clients, assisting with many aspects of the drug discovery process and development of novel diagnostic tests.

Main responsibilities will include:

- Overseeing the installation of an LC-MS/MS system and performing day to day running of the system.
- Ensuring the instrument is kept in good working order, and performing troubleshooting when issues arise. Interacting with instrument engineers to schedule instrument maintenance visits and repair.
- Development of extraction methodologies for a variety of compounds (including small molecules, peptides and proteins).
- Developing LC-MS/MS methodologies for quantifying analytes in biological matrices.
- Performing validation exercises to ensure methodologies can support preclinical studies.
- Preparing GxP study documentation such as method validation plans and reports, method work sheets, study plans and reports.
- Ensuring studies are carried out to GxP standards, and ensuring the integrity of data.
- Interfacing with the QA department to address comments and findings on reports and plans.
- Interacting with clients in the capacity of Study Director (or equivalent), discussing project progress and status.
- Liaising with business development and management to grow the LC-MS/MS business.

Key attributes and qualifications:

- Must have an expertise in the day to day running of LC-MS instrumentation.
- Significant experience in developing methodologies for extracting and quantifying analytes from a variety of matrices, including plasma, urine and tissue.
- Experience in handing a wide variety of small molecules is essential, experience of peptide and protein analysis is highly beneficial.
- Experience in a laboratory working to GLP essential.
- Experience as a GLP Study Director (or equivalent) highly preferable and experience of an MHRA inspection would be an advantage.
This is an excellent opportunity with great potential for growth and advancement within a small, friendly, dynamic, scientifically-focussed CRO.

If this opportunity is of interest please submit your CV and covering letter, and we will look forward to reviewing your application.

If you require further information please contact Katie Roddis on 01223 463300 or at